CRYOPRESERVATION OF HUMAN PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES IS NOT DETRIMENTAL TO THEIR MOLECULAR AND FUNCTIONAL PROPERTIES

Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a powerful platform for in vitro modelling of cardiac diseases, safety pharmacology and drug screening.All these applications require large quantities of well-characterised and standardised batches of Eyewear Case hiPSC-CMs.Cryopreservation of hiPSC-CMs without a

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Prevention of CSF leak from the spinal operation site due to either traumatic or iatrogenic injury to the Dura.

Background: Cerebrospinal fluid leak is a relatively common problem ranging from 0.5% to 18% with traumatic or incidental injury to the Dura intra-operatively1, 2.Traumatic injury mostly occurs due to mechanical trauma with subsequent thecal sac laceration mainly in the thoracolumbar region.Incidental Dural injury commonly happens in patients under

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Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper

Monoclonal antibodies (mAbs) deliver great benefits to patients with chronic and/or severe diseases thanks to their strong specificity to the therapeutic target.As a result of this specificity, non-human primates (NHP) are often the only preclinical species in which therapeutic antibodies cross-react with the target.Here, we highlight the value and

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